A simple, precise, accurate and reproducible spectrophotometric method has been developed for simultaneous estimation of Amlodipine besylate and Indapamide by employing first order derivative zero crossing method in methanol. The first order derivative absorption at 224 nm (zero cross point of Indapamide) was used for quantification of Amlodipine besylate and 237 nm (zero cross point of Amlodipine besylate) for quantification of Indapamide. The Linearity range 10-60 and 5-30 μg/ml for both Amlodipine besylate and Indapamide. The % recoveries of the both the drugs were found to be 98.8 – 102.2 % and 100 – 102.5 % Amlodipine besylate and Indapamide respectively. The proposed method has been validated as per ICH guidelines and successfully applied to the estimation of Amlodipine besylate and Indapamide in their combined Tablet dosage form.
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